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KMID : 1225720130050010034
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Allergy, Asthma & Immunology Research : AAIR
2013 Volume.5 No. 1 p.34 ~ p.41
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Association Analysis Between FILIP1 Polymorphisms and Aspirin Hypersensitivity in Korean Asthmatics
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Kim Jason Yongha
Kim Jeong-Hyun
Park Byung-Lae
Pasaje Charisse Flerida A.
Bae Joon-Seol
Park Jong-Sook
Jang An-Soo
Uh Soo-Taek
Kim Yong-Hoon
Kim Mi-Kyeong
Choi Inseon S.
Cho Sang-Heon
Choi Byoung-Whui
Park Choon-Sik
Shin Hyoung-Doo
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Abstract
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Purpose: Aspirin exacerbated respiratory disease (AERD) results in a severe asthma attack after aspirin ingestion in asthmatics. The filamin A interacting protein 1 (FILIP1) may play a crucial role in AERD pathogenesis by mediating T cell activation and membrane rearrangement. We investigated the association of FILIP1 variations with AERD and the fall rate of forced expiratory volume in one second (FEV1).
Methods: A total of 34 common FILIP1 single nucleotide polymorphisms (SNPs) were genotyped in 592 Korean asthmatic subjects that included 163 AERD patients and 429 aspirin-tolerant asthma (ATA) controls.
Results: This study found that 5 SNPs (P=0.006-0.01) and 2 haplotypes (P=0.01-0.03) of FILIP1 showed nominal signals; however, corrections for the multiple testing revealed no significant associations with the development of AERD (Pcorr>0.05). In addition, association analysis of the genetic variants with the fall rate of FEV1, an important diagnostic marker of AERD, revealed no significant evidence (Pcorr>0.05).
Conclusions: Although further replications and functional evaluations are needed, our preliminary findings suggest that genetic variants of FILIP1 might be not associated with the onset of AERD.
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KEYWORD
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Filamin A interacting protein 1, single nucleotide polymorphism, haplotype, asthma, aspirin exacerbated respiratory disease
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